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Additional exposure of the organoids to P4 or MPA, together with activation of cAMP signaling, creates a decidualized endometrial phenotype comparable to the in vivo situation [53, 54, 64]

Continuous Support: NAC helps maintain a steady internal production loop

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Ethics declarations Ethics Approval and Consent to Participate This research protocol has been approved by the Ethics Committee of Shenzhen Maternity and Child Care Hospital, Women and Children s Medical Center of Southern Medical University (ethics number: SFYLS [2024] 060)

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doi: 10.1002/advs.202411479 30 GuoJSatohKTabataSMoriMTomitaMSogaT